Structural Requirements for the Procoagulant Activity of Nucleic Acids

Structural Requirements for the Procoagulant Activity of Nucleic Acids

Nucleic acids, especially extracellular RNA, are exposed following tissue- or vessel damage and have previously been shown to activate the intrinsic blood coagulation pathway in vitro and in vivo. Yet, no information on structural requirements for the procoagulant activity of nucleic acids is available. A comparison of linear and hairpin-forming RNA- and DNA-oligomers revealed that all tested o...

a structural survey of the polish posters

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Structural and Biophysical Studies of Nucleic Acids

Physicochemical and Structural Aspects of Nucleic Acids

A Microfluidic Device for Structural Studies of Nucleic Acids

We assembled a microfluidic device that enables highresolution structural studies of nucleic acids. The device contains a mineral matrix capable of rapidly generating hydroxyl radicals to cleave the solvent accessible backbone of nucleic acids. Protection from radical cleavage (footprinting) can identify protein binding sites or the presence of tertiary structure. Here we report the fabrication...